Neutrophils Promote Aerogenous Spread of Lung Adenocarcinoma with Bronchioloalveolar Carcinoma Features

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Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.

PURPOSE Adenocarcinoma with bronchioloalveolar carcinoma (BAC) features is a subtype of non-small cell lung cancers characterized by an intense inflammatory reaction composed of macrophages and neutrophils and by a distinct natural history with intrapulmonary spread leading to death due to respiratory failure. We hypothesized that neutrophils could promote aerogenous spread of lung adenocarcino...

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Bronchioloalveolar carcinoma is a subtype of lung adenocarcinoma, characterized by well-differentiated cytology, peripheral location, and characteristic growth of neoplastic cells along intact alveolar septa (ie, lepidic growth pattern). Pure bronchioloalveolar carcinoma, by definition, doesn’t invade stroma, pleura, or lymphatic spaces. If there is lymphatic invasion, the tumor is classified a...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2007

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-06-2558